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Job description
ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.
With ICR, You'll Get To
Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm
Requirements
A PhD or MD/PhD
At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering
Expert knowledge in experimental therapeutics and the landscape of developmental pipelines of practical, actionable interventions to treat and prevent age-related immune senescence and achieve immune regeneration/rejuvenation
Ideally, You'll Have
Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution
Additional Requirements
A friendly, easygoing personality
The ability to work in the United States without sponsorship
Salary
Starting base pay range: $160,000/yr - $215,000/yr
Starting additional compensation range: $10,000/yr - $20,000/yr
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Worksite address
englewood, NJ, 07631, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.