About this opportunity
Tenvie Therapeutics, Inc. lists this Clinical Development Scientist/Senior Clinical Development Scientist opportunity in california, Missouri. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Clinical Scientist/Senior Clinical Scientist
TenvieTherapeuticsis developing precision‑engineered small molecule therapies to address core drivers of neurological and peripheral diseases: neuroinflammation and cellular dysfunction. Leveraging its proprietary product engine,Tenviehas the unique ability to advance both fully CNS‑penetrant and peripherally restricted products across a broad portfolio.Tenvie’smost advanced programs, TNV262 and TNV108,are in Phase 1 clinical development.TNV262isa fully CNS-penetrant NLRP3 inhibitor targeting cardiometabolicand neuroinflammatoryindications, including obesityandcardiovascular disease,andmultiple sclerosis.TNV108isa peripherally restricted SARM1 allosteric inhibitor targeting peripheral neuropathies.Tenvie’sclinical pipeline is complemented by discovery-stage programs across a range of related indications.
Tenvie Therapeutics is seeking a scientifically rigorous and highly collaborativeClinical Scientistto support the design and execution of early clinical development programs across multiple indications includingcardiometabolic and neuroinflammatory diseases. This role is ideal for candidates who have deep hands‑on study execution experience coupled with critical scientific and strategic thinking. The Clinical Scientist will work closely with Clinical Operations, Clinical Pharmacology, Biometrics, Translational Science, and Regulatory to ensure high‑quality clinical plans, protocols, and data readouts. This role can be remote, hybrid, or on‑site, and reports within the Clinical Development group.
JOB RESPONSIBILITIES:
Lead development of core clinical documentsAuthor or co‑author clinical sections ofprotocols, protocol amendments, IB updates, ICFs, clinical and scientific training material, medical monitoring plans, safety/review/ dose escalation committee charters.
Translate protocol intent into operational deliverables such as CRFs and eCRF completion guidelines, lab and pharmacy manuals. Develop or contribute to study‑level documents, including medical monitoring plans, safety review / dose escalation committee charters, data review plans, and statistical analysis plans
Draft and review clinical sections of regulatory documents and responses, including Health Authority interactions, briefing books, IND and annual reports, and safety updates
Drive study conduct and data qualityServe as Clinical Scientist lead on cross‑functional study teams for selected trials
Provide clinical and scientific input into site selection, eligibility reviews, and key study tools (e.g., manuals, training decks, CRFs)
Perform routine reviewsof patient profiles, listings, coded terms, and narratives. Monitor for trends across safety, efficacy, and protocol compliance; help define and track key data review listings and visualizations
Contribute to the interpretation of emerging clinical safety and efficacy data.
Support development and execution of safety review / dose escalation committees and data monitoring activities
Lead data interpretation and communicationLead or co‑lead integrated analyses of clinical safety/efficacy, PK/PD, and biomarker data to generate clear conclusions and next‑step recommendations
Prepare data summaries and presentations for internal governance, external collaborators, and advisory boards
Lead clinical study report authoring
Contribute to abstracts, posters, and manuscripts for scientific meetings and peer‑reviewed journals
Interface with investigators and external partnersProvide scientific support to investigators and study sites (e.g., training, protocol clarification, scientific Q&A)
Participate in KOL and expert advisory boards, contributing to agenda, content, and follow‑up
Collaborate with CROs, central labs, imaging/biomarker vendors, and other partners to ensure alignment on scientific and operational expectations
Contribute to clinical strategy and study designSupport development of clinical development plans, target product profiles, and indication prioritization
Lead or co‑lead the scientific design of Phase 1–2 studies (e.g., FIH, dose‑finding, PoC) including objectives, endpoints, inclusion/exclusion criteria, and biomarker strategy,
Integrate nonclinical, translational, and clinical data to inform dose selection, schedule, and patient population
Contribute to portfolio and organizational excellenceHelp shape clinical development best practices, templates, and processes across the portfolio
Model a culture of scientific rigor, transparency, and cross‑functional collaboration
QUALIFICATIONS:
EducationPharmD or PhD in life sciences, pharmacology, physiology, or related field strongly preferred; MD or equivalent clinical degree also considered
Strong foundation incardiometabolic biology(e.g., obesity, insulin resistance, dyslipidemia, NAFLD/NASH, cardiovascular risk) or neuroinflammation (e.g. neurodegeneration, neuropathic pain) is highly preferred
ExperienceTypically3–7+ yearsof relevant experience in clinical development, clinical pharmacology, or translational medicine within biotech/pharma or equivalent academic clinical research environment
Demonstrated experience contributing to design and execution ofearly‑phase (Phase 1–2) clinical trials
Cardiometabolic and/or obesity and/or neurologic clinical trial experience preferred,
Experience working on cross‑functional teams with Clinical Operations, Biometrics, Regulatory, and Translational/Discovery
Prior involvement inregulatory submissions(e.g., IND/CTA, briefing packages, responses to queries) is a plus
Technical skillsStrong understanding ofclinical trial methodology, GCP, and the overall drug development pathway from FIH through proof‑of‑concept
Comfort interpretingPK/PD, biomarker, and clinical efficacy/safety data, and working with statisticians and pharmacometricians
Excellentscientific writingskills with a track record of clear, structured documents and presentations
Core competenciesHighly organized, with the ability to manage multiple studies or workstreams in parallel in a fast‑paced environment
Strong analytical and critical‑thinking skills; able to move from complex data to clear, actionable recommendations
Effective communicator, able to tailor scientific messages to diverse audiences (clinicians, scientists, operations, leadership, regulators)
Demonstrated ability to workcollaboratively and constructivelyacross disciplines and with external partners
Commitment to high ethical standards, patient safety, and data integrity
Expected salary range:
$125,000-180,000 annual base salary
Tenvie is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit and business need.
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Worksite address
california, MO, 65018, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.