About this opportunity
Proclinical lists this Director DMPK opportunity in san francisco, California. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Director DMPK - Permanent, Full time- Bay Area, CA (Hybrid: 2 days onsite / 3 days remote)
Are you ready to make a groundbreaking impact in the world of biotechnology? Join a growing company that's shaping the future of healthcare and science.
Proclinical is seeking a highly motivated Director, DMPK to join an innovative, clinical‑stage biotechnology environment focused on advancing novel small-molecule therapies for immune‑mediated inflammatory diseases. This is a senior scientific leadership role offering the opportunity to shape DMPK strategy from discovery through clinical development in a fast-paced, collaborative setting.
The Role:
As Director, DMPK, you will provide technical and scientific leadership across discovery and development programs, serving as the DMPK subject matter expert and program lead. You will define and execute ADME, PK, and PK‑PD strategies, support key development decisions, and play a critical role in first‑in‑human dose predictions and regulatory submissions. You will work cross‑functionally with medicinal chemistry, toxicology, pharmacology, CMC, and clinical teams, and manage external partners to ensure high‑quality, timely DMPK execution.
Key Responsibilities
Lead and implement DMPK and PK‑PD strategies aligned with discovery and development objectives
Serve as DMPK program lead, responsible for study design, execution, analysis, interpretation, and reporting
Provide expert interpretation of DMPK data and present findings to project teams, senior leadership, and external stakeholders
Collaborate closely across R&D functions to enable data‑driven decision‑making
Oversee bioanalytical and DMPK studies conducted internally and through CROs
Author and review PK/DMPK sections of regulatory documents (IND, IB, CTA, NDA/BLA) and respond to regulatory inquiries
Support clinical pharmacology activities, including first‑in‑human dose projections
Maintain high standards of scientific rigor, quality, and documentation
Qualifications
PhD in pharmacokinetics, drug metabolism, or a related discipline
6+ years of small‑molecule DMPK experience in the pharmaceutical or biotechnology industry
Proven track record leading DMPK efforts across discovery and development
Experience with clinical candidate selection and translational PK/PD
Hands‑on experience analyzing PK and PK‑PD data using relevant software tools
Strong understanding of regulatory guidelines supporting small‑molecule drug development
Experience preparing regulatory submissions and interacting with U.S. and international regulatory agencies
Ability to oversee bioanalytical method development and validation
Leadership & Skills
Influential scientific leader with direct accountability for DMPK strategy
Excellent written and verbal communication skills
Strong analytical and problem‑solving abilities
Detail‑oriented, adaptable, and comfortable working hands‑on in a small, fast‑moving organization
Compensation & Benefits
Salary: US$190,000 - US$240,000 (commensurate with experience)
Eligibility for performance‑based bonuses and/or equity compensation
Comprehensive benefits package including health, dental, vision, 401(k), generous time‑off programs, paid parental leave, and additional insurance offerings
This role offers a unique opportunity to make a meaningful impact on the development of tansformative therapies while working alongside a passionate, high‑caliber team.
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Worksite address
san francisco, CA, 94199, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.