About this opportunity
CORE Biomedicine, Inc. lists this Director/Senior Director/VP, Drug Metabolism and Pharmacokinetics (DMPK/Clin Pharm) opportunity in northern, Kentucky. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Director/Senior Director/VP, Drug Metabolism and Pharmacokinetics (DMPK/Clin Pharm)
Company Overview:
CORE Biomedicine Inc. is a pioneering biotech startup dedicated to advancing novel therapies in oncology. We specialize in the development of small molecule drugs targeting novel pathways for the treatment of various cancers.
Position Overview:
We are seeking a dynamic and experienced individual, with strong multitasking skills to support our ongoing drug discovery and development programs. The person will lead PK/ADME/Clin Pharm for the various CORE oncology programs at various stages.
Key Responsibilities:
Work with our internal/external teams (CROs) to support various PK/ADME needs for discovery programs, including: Design suitable PK studies for ongoing discovery programs to advance from Hit-to-lead and lead optimization
Decipher ADME and metabolism profile to help medicinal chemistry to design and advance ongoing programs at various stages
Help to characterize lead candidates with preferred PK/ADME profile based on their chemical and pharmacology properties
Use various animal PK/PD data and modeling, to project potential clinical dose range and translational strategy
Collaborate closely with medicinal chemistry, biology, pharmacology and toxicology for IND enabling studies and regulatory submissions
Work with our teams, especially our clinical team, for various clinical needs
Maintain high standards of data quality, documentation, and scientific rigor
Qualifications:
PhD in Pharmacokinetics, Pharmaceutical Sciences, Medicinal Chemistry, Analytical Chemistry, or related discipline with 3+ years of relevant industry experience, or MSc with 5+ years of pharmaceutical and biotechnology experience
Strong foundation in DMPK, ADME, and pharmacokinetics for small-molecule drug discovery, development and clinical
Experience designing and interpreting in vivo PK/ADME studies, as well drug metabolism profile
Familiarity with PK/PD modeling tools (e.g., Phoenix, MATLAB, R) is a plus
Experience working with CROs and managing outsourced studies
Excellent data analysis, problem-solving, and communication skills
Comfortable operating in a fast-paced, highly collaborative startup environment
Self-motivated, adaptable, and eager to take ownership of projects
Competitive compensation
Paid time off (vacation, holidays, and sick leave)
Flexible work arrangements (hybrid or remote options where applicable)
401k, Bonus, Equity, Healthcare (Medical, Dental, Vision)
Opportunity to work at the forefront of cancer research in a mission-driven startup environment
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Who can apply
Review the original listing for work authorization, qualifications and employer requirements.