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Denali Therapeutics

Director, Site Operations & Strategic Execution

salt lake city, UT

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About this opportunity

Denali Therapeutics lists this Director, Site Operations & Strategic Execution opportunity in salt lake city, Utah. Review the employer’s description below for duties, qualifications and application requirements.

Job description

Director, Site Operations & Strategic Execution

Key Accountabilities / Core Responsibilities

Lead and continuously improve the SLC Site Operating Model, including governance, operational processes, decision frameworks, performance management, and cross-functional execution governance.

Partner with Site Leadership and enterprise teams to align site execution with strategic priorities across manufacturing, quality, supply chain, engineering, and technical operations.

Establish and manage operational governance forums, business reviews, metrics, dashboards, and reporting processes for visibility, accountability, risk management, and data-driven decision-making.

Lead strategic initiatives and continuous improvement efforts to strengthen operational readiness, scalability, organizational agility, and long-term commercial growth.

Facilitate cross-functional coordination, resource planning and prioritization, issue resolution, and coach/mentor/develop project leadership and operational execution within the SLC organization.

Identify operational risks, execution gaps, and inefficiencies; drive mitigation and continuous operational improvement.

Qualifications / Skills

Bachelor’s degree in Engineering, Life Sciences, Operations, Supply Chain, Business, or related field; 10+ years in biotech/pharma manufacturing, technical operations, supply chain, or operational leadership.

Advanced degree preferred.

GMP-regulated environment experience leading complex cross-functional operational initiatives.

Strong understanding of biopharmaceutical manufacturing, technical operations, commercialization readiness, and/or late-stage development.

Experience with operational governance models, business processes, performance management systems, and operating cadences.

Ability to influence stakeholders without direct authority; lead in fast-paced, ambiguous environments.

Strong strategic thinking, operational problem-solving, and executive communication.

Preferred: experience with operational metrics/dashboards; manufacturing readiness, PPQ execution, launch readiness, or operational scale-up.

Working knowledge of GMP and FDA/international regulatory requirements; ability to travel as required.

Benefits (as stated)

Competitive total rewards package including 401k, healthcare coverage, and ESPP.

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Worksite address

salt lake city, UT, 84193, US

Who can apply

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