Histology Core Facility Director

Job description

Position Description

Cold Spring Harbor Laboratory is seeking an experienced and highly collaborative Ph.D. or M.D. scientist for an immediate opening as Director of the Histology Core Facility. The successful candidate will provide strategic, operational, and scientific leadership for a busy, growing histology core supporting cutting‑edge basic and translational research programs in areas such as cancer biology, neuroscience, and spatial biology. The Histology Core Facility is part of CSHL’s NCI Cancer Center Animal and Tissue Imaging Shared Resource, but provides services to the entire CSHL research community.

This position requires a strong leader and manager with demonstrated experience overseeing personnel, laboratory operations, workflow optimization, and customer engagement in a research core environment. In addition to ensuring outstanding day‑to‑day operations, the Director will be expected to develop and execute a forward‑looking vision for the future growth of the Histology Core, including expansion of capabilities in digital pathology, advanced image analysis, multiplex imaging, and integration with spatial biology workflows across the institution.

The successful candidate will join a vibrant, collaborative scientific community at Cold Spring Harbor Laboratory and work closely with investigators and institutional core facilities, including the Single Cell Biology Core, to develop and implement emerging technologies in areas such as spatial transcriptomics, multiplex imaging, quantitative pathology, and computational tissue analysis. The Histology Core currently includes four histology technicians, including several highly experienced senior staff members with extensive core facility expertise.

Position Responsibilities

The Director of the Histology Core Facility will oversee all day‑to‑day operations of the core facility, including personnel management, project coordination, quality control, budgeting input, equipment oversight, and customer interactions, as well as optimizing existing workflows for improved throughput and efficiency.

In addition to operational leadership, the Director will help shape the core’s strategic scientific direction by identifying, developing, and implementing emerging technologies and analytical approaches that enhance institutional research capabilities.

Provide leadership, supervision, mentoring, and professional development for core facility staff

Manage and improve operational workflows, turnaround times, communication, and project tracking systems

Develop and execute a strategic vision for the growth and modernization of the Histology Core

Expand institutional capabilities in digital pathology, whole‑slide imaging, immunofluorescence (IF), and immunohistochemistry (IHC), and quantitative image analysis

Build integrated workflows with the Single Cell Biology Core to support spatial transcriptomics and spatial biology applications

Consult with investigators on experimental design, tissue processing strategies, histological methods, and image analysis approaches

Oversee and participate in experimental workflows, including tissue processing, embedding, sectioning, staining, IF/IHC, and in situ hybridization

Develop, validate, and implement new histology, imaging, and analytical workflows

Advise on acquisition, optimization, maintenance, and utilization of instrumentation and core technologies

Support digital pathology and image analysis workflows, including whole‑slide imaging and quantitative image analysis

Collaborate with institutional investigators and other core facilities on emerging technologies, including multiplex and cyclic immunofluorescence, spatial transcriptomics, and computational pathology approaches

Support institutional grant applications and reporting requirements, including renewals of the Cancer Center Support Grant and progress reports

Participate in all Cancer Center activities, including advisory boards and grant reviews, as requested by the Cancer Center leadership

Position Requirements

Education

An advanced degree in the biological sciences (PhD or MD) is preferred; candidates with a master’s or bachelor’s degree and extensive histology experience will also be considered.

Skills and Experience

At least 3 years of experience working in a histology, pathology, or related academic core facility

Demonstrated experience helping develop or expand core facility technologies, workflows, or scientific capabilities

Experience managing or supervising technical staff within a shared‑resource or service‑oriented environment

Expertise in digital pathology, whole‑slide imaging, and/or quantitative image analysis

Experience with image analysis platforms such as Visiopharm, HALO, QuPath, or related software

Experience with advanced multiplex imaging approaches, including cyclic immunofluorescence and spatial biology workflows

Computational and analytical experience related to image analysis, including cell phenotyping, spatial/neighborhood analysis, and high‑dimensional imaging datasets

Experience integrating histology and imaging workflows with spatial transcriptomics or single‑cell technologies

Experience evaluating, implementing, and optimizing new instrumentation and technologies

Compensation and Benefits

Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, a wellness center, and access to an affordable and licensed on‑site childcare center.

Equal Opportunity Employer

CSHL is an EO Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status. VEVRAA Federal Contractor.

#J-18808-Ljbffr

Worksite address

cold spring harbor, NY, 11724, US

Who can apply

Review the original listing for work authorization, qualifications and employer requirements.