About this opportunity
St. Jude Children's Research Hospital, Inc. lists this Lead or Senior Scientist - Genome Editing, Genomics, Biotechnology (Shengdar Q. Tsai Lab) opportunity in memphis, Tennessee. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Lead or Senior Scientist Opportunity
A Lead or Senior Scientist opportunity with the Tsai Lab to develop a therapeutic platform for in vivo base editing treatments and drug products to treat patients with bone marrow failure disorders at St. Jude. Help us build an individualized therapeutic base editing platform to treat St. Jude patients with rare bone marrow failure disorders by correcting their disease‑causing mutations in their hematopoietic stem cells in vivo. Dr. Tsai leads the recently launched DRIVE project (Delivering Rare‑disease In vivo Editors), funding a multi‑institutional, public‑private partnership to develop in vivo base editors for treatment of bone marrow failure disorders. Bring your expertise in genome editing drug development to a Lead Scientist role in the Tsai Lab, where you will help advance genome editing technologies toward individualized treatments for pediatric patients. Our goal is to develop in vivo base editing drug products, complete IND‑enabling studies, and open clinical trials in the next 3 years.
About the Job Opportunity
We are seeking an outstanding and highly motivated Lead Scientist or Senior Scientist to help lead efforts to develop personalized genome editing treatments. We care deeply about the success of our scientists, and this is a unique opportunity to help lead development of an in vivo gene therapeutic gene editing platform and drug products at St. Jude, with substantial room for career growth and advancement.
Overview of the Lab
The Tsai lab is a highly collaborative, creative, and motivated group of scientists at St. Jude Children’s Research Hospital. Our research centers on development of state‑of‑the‑art genomic methods for understanding the global activities of genome editors, protein engineering to improve capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies. Dr. Tsai also co‑leads the PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) blue sky project.
Key Responsibilities
Design and develop in vivo base editing drug products to treat St. Jude patients with bone marrow failure disorders.
Characterize the genotoxicity of candidate drug products using state‑of‑the‑art genomic assays such as CHANGE‑seq‑BE and CHANCE‑seq, including variant‑aware analysis.
Optimize potency and specificity of a HSC‑targeted lipid nanoparticle gene editing approach.
Co‑lead a multi‑disciplinary team to test a new streamlined platform approach for in vivo genome editing medicines.
Coordinate a team of scientists working to develop a novel gene editing platform.
Accelerate lead‑target discovery, genotoxicity characterization, and cargo optimization.
Non‑clinical pharmacology studies of an HSC‑targeted lipid nanoparticle.
Continuously assess and manage project technical and drug development risks.
Analyze experimental outcomes and develop high‑quality summaries.
Summarize results and present updates to the broader DRIVE and ARPA‑H teams.
Draft manuscripts and figures for publication in high‑impact journals.
Project‑Dependent Responsibilities
You would learn valuable skills that include: Genome engineering, high‑throughput genomics, laboratory automation, IND‑enabling studies for genome editing drug development.
Minimum Education and/or Training
PhD in relevant scientific area is required, such as genomics, molecular and cell biology.
Expertise in genome editing, genomics, next‑generation sequencing.
Excellent communication, organizational, and presentation skills.
Four or more years of hands‑on research laboratory experience working with CRISPR genome editors and NGS library preparation.
Lead Scientist Minimum Experience
Twelve (12) years of relevant work experience is required with a Bachelor’s degree.
Ten (10) years of relevant experience is required with a Master’s degree.
Seven (7) years of relevant work experience is required with a PhD.
Lead Scientist Salary Range
$125,840.00/yr. - $238,160.00/yr.
Senior Scientist Minimum Experience
Ten (10) years of relevant work experience is required.
Eight (8) years of relevant work experience is required with a Master’s degree.
Five (5) years of relevant work experience is required with a PhD.
Senior Scientist Salary Range
$104,000/yr. - $186,160.00/yr.
St. Jude Benefits
St. Jude Children’s Research Hospital is one of the world’s leading pediatric hospitals whose mission is to advance cures for catastrophic childhood diseases.
Consistent with the vision of our founder, no child is denied treatment based on race, religion, or ability to pay.
St. Jude has been consistently named one of the best companies to work for by Fortune, Glassdoor, and others.
St. Jude offers excellent benefits, a competitive salary, relocation assistance, and actively fosters professional development.
As part of your role, you will have opportunities to attend and present at national and international meetings such as ASGCT, ASH, Keystone Genome Engineering, CSHL Genome Editing, and FASEB Genome Engineering.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Lead or Senior Scientist - Genome Editing, Genomics, Biotechnology (Shengdar Q. Tsai Lab). Explore our exceptional benefits!
Employer Commitment
We are committed to a human‑centered hiring experience. Technology may support portions of our process, but recruiting decisions involve human review and engagement. Learn more about our approach to AI.
Equal Opportunity Employer
St. Jude is an Equal Opportunity Employer
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Worksite address
memphis, TN, 37544, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.