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Job description
A well-funded clinical-stage biotech developing targeted therapies and imaging agents is hiring a synthetic organic chemist to own its fluorophore program end to end: from bench synthesis through GMP scale-up and CMC.
This is a hands-on role with real ownership. You will design and make the dyes, and you will be the company's technical lead with its external CMC provider.
What you'll do
Design and synthesise novel fluorophores, with an emphasis on polymethine and near-infrared dyes
Develop and optimise multistep synthetic routes, troubleshooting them from first principles
Take molecules from bench through scale-up to GMP manufacture
Act as the technical interface to the CMC provider: specifications, impurity control, batch records, campaign oversight
Support IND-stage CMC documentation
Work alongside the peptide and organic chemistry team on conjugation and bioconjugate chemistry
What you'll need
PhD in Organic Chemistry or a closely related field
Demonstrable hands-on fluorophore synthesis: dyes you have made yourself, not purchased and conjugated
GMP experience and working knowledge of the CMC section of a drug application
Track record taking chemistry from laboratory scale to GMP manufacture
Click chemistry and bioconjugation
Excellent safety record with organic solvents, oxidising agents and flammables
Someone who reasons past a failed reaction rather than stopping at "it doesn't work"
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Worksite address
cape coral, FL, 33990, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.