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Regeneron Pharmaceuticals, Inc.

Principal Scientist, Neuroscience / Genetic Medicine

village of tarrytown, NY

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About this opportunity

Regeneron Pharmaceuticals, Inc. lists this Principal Scientist, Neuroscience / Genetic Medicine opportunity in village of tarrytown, New York. Review the employer’s description below for duties, qualifications and application requirements.

Job description

Build our future together: At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Principal Scientist to join our Genetic Medicines team, helping advance the preclinical development of targeted genetic medicines for disorders of the central nervous system. In this role, you will design and lead experiments across CNS disease models, working as part of a collaborative, multidisciplinary team spanning platform technology, disease biology, and early clinical development. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & Where

Location: Tarrytown, NY

Work model/flexibility: Onsite

Discover your role

Design experiments to evaluate the efficacy, target engagement, and delivery efficiency of viral and non‑viral therapeutic candidates across CNS disease models

Design AAV transgene cassettes to optimize therapeutic efficacy

Lead a team of associates in the execution of experiments and analysis of primary data

Interpret complex datasets, integrating findings with current scientific literature to propose data‑driven next steps

Communicate project strategy, scientific vision, and data updates to senior leaders

Author and review preclinical study reports to support regulatory submissions

Approach scientific problems with an engineering mindset and a design‑build‑test‑learn framework

Coach and mentor junior scientists within a multidisciplinary team environment

This role requires

Experience evaluating DNA- or RNA-based therapeutics in small‑animal models

Hands‑on experience with molecular biology techniques

Experience mentoring and managing research associates

Excellent communication and presentation skills

Preferred: Ph.D. in neuroscience, gene therapy, or a related discipline

Preferred: 5+ years of combined postdoctoral and industry experience in biotechnology, genetic medicines, or CNS drug discovery

Preferred: knowledge of both viral and non‑viral genetic medicine delivery modalities

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Salary Range (annually)

$128,600.00 - $210,000.00

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Who can apply

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