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Job description
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
Responsibilities
Leads complex, cross‑functional, and external biomarker research projects within Translational Medicine
Defines biomarker strategies that generate clinical evidence of target engagement, pathway engagement, and disease‑biomarker modulation, including biomarkers positioned as surrogate or intermediate clinical endpoints in support of accelerated approval
Contributes biomarker strategy and data packages to BLAs and other regulatory submissions, including briefing documents and responses for health authority interactions
Maintains deep scientific expertise in rare disease biomarkers such as lysosomal storage disorders while expanding knowledge of adjacent disciplines, including CNS disorders
Designs and implements biomarker assays in clinically relevant biosamples
Mentors junior scientists across lab and project‑team settings
Analyzes and interprets complex data sets, communicating results clearly across scientific, clinical, and leadership audiences
Maintains lab records consistent with good documentation practice
Contributes to patent filings, diligence reports, publications, and regulatory documents
Represents the organization at scientific conferences and through academic partnerships
Qualifications / Skills
PhD in a relevant scientific discipline (e.g., biochemistry, neurobiology, molecular biology, pharmacology) with typically 10+ years of post‑training industry and/or academic experience
Demonstrated expertise in developing, executing, and interpreting complex biomarker assays in a clinical study setting
Experience contributing to regulatory submissions (e.g., BLA, NDA, IND), particularly biomarker‑related sections and health authority interactions
Record of high‑quality publications and/or public presentations in rare disease, translational research, or biomarkers
Strong oral, written, and presentation communication skills across scientific and cross‑functional audiences
Preferred Qualifications
Experience in rare/orphan disease drug development
Direct experience supporting an accelerated approval submission, including biomarker qualification as a surrogate or intermediate clinical endpoint
Experience with lysosomal storage disorders or other rare pediatric genetic diseases
Experience with natural history studies and patient registries in rare disease settings
Direct experience in FDA/health authority meetings (e.g., Type B/C meetings, briefing documents)
Salary and Benefits
Salary Range: $171,000.00 to $223,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401(k), healthcare coverage, ESPP and a broad range of other benefits. Learn more at This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
EEO Statement
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal‑opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
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Worksite address
south san francisco, CA, 94083, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.