About this opportunity
Cascadebio lists this Process Development Scientist, Biocatalysis opportunity in denver, Colorado. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Job Title: Process Development Scientist, Biocatalysis
Location: Denver, CO (on-site)
Type: Full-time
Job Description:
Cascade Biocatalysts is building the next generation of industrial biocatalysts and is seeking a hands-on Process Development Scientist, Biocatalysis to join and lead our biocatalytic process development, intensification, and scale-up efforts.
This is a foundational role at Cascade Bio. You will be the person who builds our process development function, setting technical direction, establishing SOPs and standards, and owning the path from bench-scale proof of concept to a process that works at commercial scale. You will work directly with the founding team, with ownership over outcomes and the opportunity to shape not just the science but the culture and direction of the company.
The right candidate is a subject matter expert on commercial biocatalysis and is as comfortable running reactions at the bench as they are thinking about cost per kilogram and scale-up implications. The ideal candidate comes from a biocatalysis-focused company, CDMO, or industrial process chemistry group, and is now ready to bring that instinct and experience to a place where their work will have direct and visible impact.
Key Responsibilities
Own biocatalytic process development end-to-end, from initial hits to optimized ready to scale processes
Run and optimize enzymatic reactions, driving process intensification by improving space-time yield, reducing enzyme loading, extending catalyst lifetime, and lowering overall process costs
Collaborate with our enzyme immobilization team to evaluate and implement biocatalyst formats
Evaluate and implement new equipment and process analytical technology solutions
Lead and grow a small process development team over time, mentoring junior scientists while maintaining a technical culture and standards
Build and maintain techno-economic models tracking key process metrics: E-factor, PMI, catalyst cost contribution, and downstream processing implications
Interface with protein engineering efforts, translating process bottlenecks into enzyme engineering targets and back-integrating improved variants
Contribute broadly across the organization: at this stage of the company, the most impactful team members bring their expertise to problems beyond their core scope
Strong communication skills and ability to balance multiple priorities in a fast-paced, cross-functional and dynamic environment across a variety of programs
Qualifications
PhD or MS in biochemistry, chemical engineering, organic chemistry, or a related field with a strong biocatalysis or heterogeneous catalysis focus
Minimum of 4 years of experience in process development including scale up, continuous improvements and commercial biocatalysis development
Demonstrated ability to improve process performance against real commercial targets, including yield, cost, throughput, not just feasibility
Experience with techno-economic modeling and process analytical tools
Familiarity with DOE-driven development and comfort using data systematically to guide decisions
Experience working across disciplines, including protein engineering, analytical chemistry, and engineering, and translating between scientific and commercial priorities
Prior experience at a biocatalysis-focused company, CDMO, or industrial process chemistry group strongly preferred
Comfort operating in an early-stage environment with limited resources, ambiguity, and ambitious goals
About Cascade Biocatalysts
Cascade Bio is an equal opportunity employer. We welcome and encourage diversity in the workplace and strongly encourage candidates from all backgrounds to apply.
At Cascade Biocatalysts, we are commercializing our Body Armor for Enzymes™, a polymer science innovation that makes enzymes rugged and reliable for cost-effective biomanufacturing. Our platform unlocks the power of enzymes to replace traditional, unsustainable chemical processes and supports the buildout of a resilient and clean chemical industry.
We are a small and growing team, passionate about bridging biology and chemistry to build the future of manufacturing. If you're excited to bring enzymes out of the lab and into the world — we’d like to meet you.
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Worksite address
denver, CO, 80285, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.