About this opportunity
Orum Therapeutics lists this Project Team Leader, Biology opportunity in lexington, Massachusetts. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Lead the biology strategy and execution for one or more oncology discovery programs spanning target validation, hit-to-lead, lead optimization, and IND-enabling studies
Design and oversee in vitro and in vivo plans for degrader and degrader antibody conjugate candidates
Serve as the biology representative on cross-functional project teams with chemistry, DMPK, toxicology, CMC, and translational functions
Translate research strategy into workplans, timelines, and go/no-go criteria; anticipate risks and propose data-driven mitigations
Coordinate and oversee in vivo studies, including scoping, CRO selection and management, dosing design, and data integrity
Mentor and provide scientific guidance to junior scientists
Analyze, interpret, and communicate data and program status to research leadership and the broader organization
Contribute to target evaluation, portfolio strategy, and new program concepts
Requirements
PhD in cancer biology, molecular/cell biology, pharmacology, biochemistry, or a related field, with 8+ years of experience, or a Master's degree with 12+ years of commensurate experience
Demonstrated record of independently leading discovery programs
Demonstrated track record advancing oncology discovery programs toward IND
Program-level or hands-on experience with targeted protein degradation, including E3 ligase biology, molecular glues and/or PROTACs, ternary complex formation, and degradation assays
Experience with antibody-drug conjugates, including target/antigen selection, internalization, linker-payload biology, DAR, bystander effect, and characterization
Ability to design and interpret in vivo oncology pharmacology studies, including xenograft/PDX, PK/PD, and efficacy
Experience managing CRO-run studies
Strong record of cross-functional collaboration across discovery and development
U.S. citizenship or authorization to work in the U.S.; employer unable to sponsor or transfer at this time
Ability to pass a background investigation
Core Competencies
Expertise in leading oncology discovery programs, including target validation and IND-enabling studies, with a strong focus on targeted protein degradation and antibody-drug conjugates. Proven ability to mentor junior scientists and collaborate cross-functionally to drive research strategy and execution.
Highest-signal resume keywords
PhD In Cancer Biology
Targeted Protein Degradation
Antibody-Drug Conjugates
In Vivo Oncology Pharmacology Studies
Cross-Functional Collaboration
ATS Optimization Keywords
Hard Skills
Target Validation
Hit-To-Lead
Lead Optimization
IND-Enabling Studies
E3 Ligase Biology
Molecular Glues
Degradation Assays
Xenograft/PDX Studies
PK/PD Analysis
Efficacy Studies
Soft Skills
Mentoring
Scientific Guidance
Data Communication
Industry Keywords
Oncology
Pharmacology
Biochemistry
Molecular Biology
Cancer Biology
Tools & Technologies
CRO Management
Dosing Design
Data Integrity
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Worksite address
lexington, MA, 02173, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.