About this opportunity
BigHat lists this Scientist I, Display Technologies opportunity in san mateo, California. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Scientist I, Display Technologies
Department: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
Description
The role: BigHat Biosciences is seeking a curious and motivated Scientist 1 to join the Display Technologies team. This individual will contribute to BigHat's antibody discovery and engineering efforts and help generate high-quality data to improve BigHat's machine learning models using display technologies, working closely with senior scientists and cross-functional teams.
Key Responsibilities
Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models.
Lead in the construction and QC of phage display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
Execute standard phage display selections to engineer antibodies with desired therapeutic properties.
Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
Analyze selection results and contribute to discussions on next steps and future experimental design.
Collaborate with BigHat's Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components.
Present experimental plans and results during regular meetings with manager and science teams.
Effectively and regularly communicate results to key decision makers, the broader BigHat team, and to external partners.
Maintain thorough records using LIMS and electronic notebooks.
Skills Knowledge and Expertise
Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related field, with up to 2 years of industry research experience; or an M.S. in a related field with 6+ years of relevant industry research experience.
Experience with display technologies, including library design and selection strategies.
Knowledge of antibody biology and protein expression.
Strength in general molecular biology techniques (PCR, molecular cloning, gel electrophoresis).
Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms.
Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records.
Effective time management and clear written and verbal communication skills.
Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
Scientific track record and publication record.
Strong data analysis and interpretation skills. Experience working with agentic software tools is a plus.
Total Rewards
The salary estimated for this position is $120,000 - $145,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
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Worksite address
san mateo, CA, 94409, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.