Scientist II

Job description

HD Biosciences Inc. , a WuXi AppTec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceutical clients. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services.

We are seeking an initiative-taking and skilled scientist to join our fast-growing bioanalysis team. The position will independently design, execute, trouble shoot and deliver the projects with LC-MS (liquid chromatography – mass spectrometry), prioritizing large molecules such as biologics, peptides, ADCs (antibody drug conjugates), LNPs (lipid nanoparticles), and oligos, and including small molecule modalities when necessary.

Key Responsibilities

This is a laboratory-based role. Hands-on bench work is required

Provides scientific and operational support for bioanalysis group

Actively contributes and applies expertise and knowledge to collaborations with partners in the design and execution of related studies

Contributes to project proposal preparation

Leads ongoing projects to meet expected timelines

Contributes for new capability implementation and team building

Contributes to the overall operations and to the achievement of departmental goals

Communicates with clients for designing, analysis, reporting and recording activities

Performs job specific tasks in compliance with applicable Regulations, International Standards, WuXi AppTec Policies and Standard Operating Procedures

PhD with 4+ years of relevant industry experience, MS with 7+ years of experience in Bioanalysis and Mass Spectrometry, and/or related field

Strong scientific knowledge and hands-on technical expertise in LC-MS-based bioanalysis and drug discovery workflows. Industry experience in a CRO environment is highly desirable

Demonstrated experience supporting ADC, biologic, LNP, small-molecule and/or oligonucleotide programs is strongly preferred.

Technical expertise:

Solid understanding of qualitative and quantitative LC-MS workflows for ADCs, LNPs, peptides/proteins, biologics, small molecules, including associated sample preparation techniques

Strong competency with a broad range of LC-MS instrumentation, including triple quadrupole (QQQ), QTOF, and Orbitrap platforms

Hands‑on experience with LC-MS method development, optimization, troubleshooting

Experience developing and executing ADC bioanalytical assays, including characterization and/or quantification of ADCs, antibody/antibody‑drug conjugate components, payloads, metabolites and relevant catabolites

Experience with LNP analysis by LC-MS, including characterization and/or quantitative analysis of LNP‑associated components, lipid components, payloads or related analytes

Experience with DMPK and bioanalysis, including quantitative analysis of drug candidates and metabolites in biological matrices

Strong experience with sample preparation from tissues, cells, plasma/serum, and other biofluids

Proficiency with relevant data analysis and bioinformatics software, such as Skyline

Prior experience with in vitro assays and/or ex vivo pharmacology studies supporting drug discovery programs is a plus

Willingness and ability to lead or support studies beyond the LC-MS area, including cross‑functional projects and drug discovery activities as needed

Knowledge / Skills / Abilities

Demonstrated time management and multi‑tasking skills, ability to effectively prioritize workload and manage changes in direction

Demonstrated ability for attention to details and concern for impact

Effective communication skills with the ability to give and receive feedback, both verbally and in writing

Ability to work in a team environment and independently as required.

Ability to work in a fast‑paced environment

Well organized and adaptable to changes

Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint. Ability to learn instrument and data analysis software

Physical Requirements

Must be able to work in an office environment with minimal noise conditions

Must be able to work in a lab setting with exposure to Animals/biohazards /Chemicals (List specific Chemicals)

Must not have animal allergies to applicable species in this facility

Must be able to work in environment with variable noise levels

Ability to stand/Sit/walk for long periods of timeAbility to Lift 10 lbs routinely

Ability to push/pull 10 lbs. routinely/often/occasionally

Clarity of vision

Ability to identify and distinguish colors

Must be able to perform activities with repetitive motions

Ability to climb ladders/stairs/scaffolding

Ability to work in variable temperatures high to freezing

Inside/outside working conditions

Anticipated base pay range: $82,731 to $107,132

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability

This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job‑related duties as requested by Management.

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Worksite address

san diego, CA, 92189, US

Who can apply

Review the original listing for work authorization, qualifications and employer requirements.