About this opportunity
R&D Partners lists this Scientist opportunity in san jose, California. Review the employer’s description below for duties, qualifications and application requirements.
Job description
We are seeking a highly motivated and intellectually curious Scientist to support the discovery and optimization of multi-specific T Cell Engagers. The successful candidate will generate high-quality, decision-enabling data across early discovery through IND-enabling studies. This role combines deep hands-on experimental expertise with scientific leadership, assay innovation, and cross-functional collaboration to advance organization's multi-specific pipeline.
This is a full time position based in San Jose, California.
Responsibilities:
Contribute to the design of multi-specific antibodies and oversee their production/purification.
Design, execute, and lead in vitro functional studies supporting the validation of target combinations, lead selection, and preclinical development of multi-specific TCEs.
Develop, optimize, and perform functional assays to inform potency, selectivity, and safety. (e.g., cytotoxicity, cytokine release, reporter assays).
Generate and interpret complex datasets with a strong emphasis on scientific rigor, reproducibility, and data quality.
Build decision-focused data packages and communicate clear scientific conclusions and recommendations to project teams and management.
Familiarity with diverse antibody platforms and strategies for the design and production of multi-specific antibodies.
Optimize and characterize binding properties of multi-specific antibodies (ELISA, flow cytometry, cell bridging assays).
Develop and execute multiparameter flow cytometry to assess T-cell activation.
Design and perform real-time cytotoxicity assays (e.g., IncuCyte, eSight) and other functional readouts relevant to T-cell engager activity (e.g., reporter assays).
Design and generate engineered cell systems, including overexpression and CRISPR-based knockout models.
Isolation and maintenance of primary immune cell populations (e.g., PBMCs, T-cells).
Proactively identify project risks, propose mitigation strategies, and communicate progress and challenges clearly to stakeholders.
Adhere to Quality Management System (QMS), including SOPs, documentation standards, electronic lab notebooks, and required training.
Qualifications:
PhD with 1-3 years of relevant post-PhD experience, or MS with 5-7 years of relevant industry experience in immunology, cell biology, or biologics discovery.
Experience supporting the discovery, characterization, and optimization of T-cell engagers, bispecific antibodies or other immune redirecting biologics.
Experience with stable cell line generation (Lentiviral transduction, CRISPR KO).
Expertise with antibody binding assays (ELISA, flow cytometry).
Immune cell co-culture cytotoxicity assays with live readouts (Incucyte, eSight).
Multiparameter flow cytometry and panel design.
T-cell activation assays (Reporter assays, immune-profiling and cytokine secretion).
Demonstrated ability to design, analyse, and interpret complex datasets and translate results into clear scientific conclusions.
Experience with affinity tuning/detuning and epitope selection to achieve logic-gated targeting
Hands on experience with complex co-culture systems (e.g., organoids)
Experience managing cross-functional/CRO studies related to in vivo cancer models
Experience contributing to biologics discovery programs from early discovery through lead optimization and/or preclinical development.
Track record of scientific impact demonstrated through publications, patents, presentations, or program advancement.
$125,000-$145,000
R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.
R&D Partners is an equal-opportunity employer.
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Worksite address
san jose, CA, 95199, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.