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Job description
Scientist, Tissue Engineering (Organ Manufacturing Group)
Responsibilities
Design and execute in vitro experiments using adult and iPSC-derived lung cells (endothelial and epithelial) to develop functional tissue on 3D-printed models.
Develop and implement strategies and analytic assays to optimize culture systems, co-culture techniques, and large-scale bioreactors for pulmonary tissue engineering.
Develop and implement analytical assays (immunocytochemistry, biochemical assays, metabolic readings, perfusate analysis, gene expression analysis) to evaluate tissue formation and maturation on 3D printed models.
Record experimental details in electronic notebook entries, write project reports, and internally present research findings.
Coordinate with supervisor on project directions, experimental planning, and progress review.
Contribute to IP, regulatory filings, and journal publications, if necessary.
Maintain communication with internal cross-functional R&D team and external vendors/consultants.
Perform other duties as assigned.
Minimum Requirements
PhD in Biology, Biomedical Sciences, Tissue Engineering, Bioengineering (or equivalent).
3+ years prior research experience related to pulmonary biology, endothelial biology, iPSC-derived lineages, tissue engineering, and/or novel cell culturing contexts (graduate experience considered).
2+ years industry and/or postdoctoral training.
Strong technical experience: imaging (microscopy, confocal, image analysis) and biological analytical assays (immunocytochemistry, gene expression analysis, ELISAs, flow cytometry, viability assays, etc.).
Track record of success with at least one first-author publication.
Experience in endothelial cell biology/vascular tissue engineering with knowledge of pulmonary biology, epithelial cells, and/or stem cell-derived lineages.
Understanding of tissue engineering concepts and field.
Knowledge of endothelial biology/cell-cell interactions, ECM production, or co-culture.
Ability to recommend long-term project plans based on scientific data.
Familiarity with cell-blood interactions, thrombogenic and inflammatory responses.
Experience with perfusate analytics, secretome characterization, cellular metabolism, gene expression profiling, and cell-cell signaling in complex tissue culture systems.
Experience or interest in large-scale bioreactors/perfusion culture.
Preferred Qualifications
2+ years leading a project team (e.g., products, grants, and/or publications).
Methods to evaluate endothelial cell health in vitro (tube formation/angiogenesis assay).
Proficiency with microfluidics, bioreactors, and/or dynamic culture techniques.
Location
- Fully onsite in Manchester, NH.
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Worksite address
manchester, NH, 03103, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.