Senior Director, Financial Planning & Analysis - R&D

Job description

Our commitment to people with neuromuscular diseases

is our greatest strength

Senior Director, Financial Planning & Analysis – R&D

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at , and follow us on X , LinkedIn and Facebook .

Role Summary:

The Senior Director, FP&Aservesas a strategic finance leader responsible for advancing Dyne’s financial planning, forecasting, reporting, and decision-support capabilities acrosstheResearch & Development organization. This rolepartnersclosely with Finance leadership, the CFO, functional leaders, program and project teams, and cross-functional stakeholders to translate scientific, operational, and corporate priorities into disciplined financial plans, actionable insights, and clear executive-level recommendations.

This leader is a strategic leader who inspires action, manages interdependencies, allocatesresources effectively, and influences decisions across functions. The role requires deep FP&Aexpertise, strong business judgment, and the ability to synthesize complex financial, operational, and portfolio information to guide planning, investment decisions, scenario modeling, resource allocation, and long-range financial strategy. This leaderstrengthensscalable FP&A processes, tools, reporting, and operating rhythms to support Dyne’s continued growth and mission of delivering meaningful outcomes for patients.

This role is based in Waltham, MA.

Primary Responsibilities Include:

Lead annual budgeting, quarterly forecasting, long-range planning, and scenario modeling processes across R&Dfunctions: Research, Clinical Development, RegulatoryandPortfolioStrategy&Operationsand thecross-functionalprogramleadership team

Partner with the VP, FP&A to develop, manage, and continuously improve Dyne’s enterprise planning calendar, planning assumptions, financial models, templates, reporting packages, and governance processes

Serve as a trusted finance business partner to R&Dfunctions: Research, Clinical Development, Regulatoryand Portfolio Strategy & Operationsand the cross-functional program leadership team ,providingfinancial insights that support strategic decision-making, portfolio prioritization, operating discipline, and resource allocation

Translate program timelines, clinical development plans, headcount plans, vendor commitments, and functional priorities into clear financial forecasts and actionable recommendations

Partner closely with the program leadership team and Clinical Operations to develop and manage a live clinical trial forecasting model that clearlyidentifieskey assumptions and drivers, enabling robust scenario planning and informed investment decisions

Lead program- and function-level budget reviews, challenging assumptions,identifyingrisks and opportunities, and ensuring alignment between financial plans, corporate goals, program milestones, and functional priorities

Develop andmaintainrobust financial models, dashboards, and reporting tools that provide visibility into spend, cash runway, operating performance, clinical and program costs, headcount, and key business drivers

Prepare and present executive-ready financial analyses, variance explanations, forecast updates, and recommendations for Finance leadership, the CFO, senior leadership, and other governance forums as needed

Lead monthly and quarterly actuals reporting, variance analysis, accrual support, and close-related FP&A activities in partnership with Accounting, Procurement, and functional budget owners

Partner with Accounting to ensureappropriate expenserecognition, accrual accuracy, budget-to-actual transparency, and alignment with US GAAP, SOX requirements, and company policies

Support strategic analyses related to capital planning, cash runway, business development opportunities, program investment decisions, launch readiness, and other enterprise priorities

Identify, implement, and scale process improvements that increase forecast accuracy, planning discipline, reporting consistency, transparency, and efficiency across the FP&A function

Support implementation, optimization, and adoption of financial planning systems and enterprise tools, including planning applications, reporting dashboards, and related integrations

Foster accountability and financial ownership across the organization by enabling clear communication, practical guidance, and consistent operating rhythms with functional leaders and budget owners

Build, coach, and develop FP&A talent as the function evolves, creating a collaborative, inclusive, high-performing team culture grounded in Dyne’s values

Model Dyne’s core values by leading with purpose, accountability, transparency, collaboration, sound judgment, and a commitment to continuous improvement

Perform ad-hoc financial analysis and support special projects asrequired

Education and Skills Requirements:

Bachelor’s degree in Finance, Accounting, Economics, Business, or a related field

Advanced degree, CPA, CFA, or MBA preferred

15+ years of progressive finance, FP&A, corporate finance, strategic finance, or related experience, preferably in biotechnology, pharmaceuticals, life sciences, or another high-growth R&D-driven environment

8+ years of experience leading people, teams, major workstreams, or a finance function, directly or through cross-functional leadership

Strong understanding of biotechnology financial drivers, including R&D investment planning, clinical developmentspend,ROI analysis, program timelines, vendor commitments, headcount planning, operating expense management, and cash runway considerations

Experience building andmaintaininglive clinical trial forecasting models, with the ability toidentifykey cost assumptions and drivers and support scenario planning across clinical programs

Demonstrated ability to lead annual planning, forecasting, long-range planning, management reporting, scenario analysis, and executive-level financial presentations

Experience partnering with R&D, Clinical Development, CMC, Technical Operations, Commercial, G&A, or other functional leaders to align operating plans with corporate strategy and financial targets

Strong working knowledge of US GAAP, SOX requirements, accrual processes, budget-to-actual reporting, financial controls, and close-related FP&A responsibilities

Deep financial modeling, analytical, and problem-solving skills, with the ability to synthesize complex data into clear insights, recommendations, and trade-off decisions

Demonstrated ability to influence senior stakeholders, reconcile multiple perspectives, manage interdependencies, and drive outcomes in a matrixed environment without relying solely on formal authority

Proven ability to build scalable processes, reporting infrastructure, financial models, dashboards, and planning tools that improve transparency, accountability, and decision-making

Strong executive presence and communication skills, including the ability to prepare and deliver concise,accurate, and compelling materials for senior leaders and governance forums

Highproficiencywith Microsoft Office products, especially Excel and PowerPoint; experience with financial planning systems, ERP systems, and reporting tools preferred

Strong organizational and project management skills, with the ability to manage multiple priorities, meet tight deadlines, andmaintainhigh-quality work in a fast-paced environment

Sound judgment, high integrity, attention to detail, and commitment to compliance, confidentiality, and financial discipline

Collaborative, solutions-oriented leader who builds trust, empowers others, promotes accountability, and contributes to a positive and inclusive team culture

Excitement about Dyne’s mission, operating environment, and core values

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MA Pay Range

$233,000 — $285,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Worksite address

waltham, MA, 02254, US

Who can apply

Review the original listing for work authorization, qualifications and employer requirements.