Senior Director, Protein Analytics & Biophysics

Job description

Generate:Biomedicines is seeking a scientifically bold, highly collaborative Senior Director to lead Protein Analytics & Biophysics within our Therapeutics division. This leader will set the vision for how Generate measures the biophysical, biochemical, and interaction properties of protein therapeutics across the design-build-test-learn cycle, from conventional analytical characterization through next-generation pooled, miniaturized, and nanoscale measurement platforms.

We are looking for a field-leading biophysicist and platform builder who has not only operated best-in-class analytical and protein interaction workflows, but has also invented, scaled, or industrialized new ways to measure protein therapeutic attributes at orders-of-magnitude higher throughput and lower sample consumption. The right person will be energized by the challenge of connecting micro- and nanoscale assay innovation with Generate's AI/ML-enabled protein design engine.

This role will own the continued excellence of conventional protein analytics, developability, and protein-protein interaction technologies while building the next generation of at-scale experimental systems. The ideal candidate brings deep technical breadth, a quantitative mindset, and a clear point of view on how pooled assays, DNA/barcode-enabled readouts, synthetic biology, automation, microfluidics, advanced detection, and computational modeling can transform how protein therapeutics are evaluated.

Success in this role will require enterprise leadership: developing leaders and senior scientists, building an inclusive and high-accountability culture, partnering deeply across Protein Sciences, Prototyping, Technology, Data Sciences, Machine Learning, Biology, and CMC/Tech Ops, and translating an ambitious scientific vision into robust capabilities that improve decision quality, speed, and scale.

Here's how you will contribute:

Set and drive the multi-year scientific and organizational vision for Protein Analytics & Biophysics, aligning functional strategy with Generate's platform, portfolio, and company priorities.

Define the next generation of biophysical, biochemical, developability, and protein-protein interaction measurement capabilities for protein therapeutics, with a particular focus on miniaturized, pooled, high-throughput, and nanoscale approaches.

Lead the continued evolution of conventional analytical and interaction workflows, including HPLC/UPLC, LC/MS, electrophoretic, thermal stability, light scattering, plate-based, and biosensor-based platforms, ensuring rigor, reproducibility, and decision relevance.

Build a strategy that connects conventional analytical and biosensor technologies with emerging pooled or massively multiplexed approaches, enabling Generate to measure protein attributes at scales that match the output of generative design.

Partner with Prototyping, Technology, Automation, Data Sciences, Machine Learning, Protein Sciences, Biology, and CMC/Tech Ops to design, operationalize, validate, and scale new assay concepts into production-quality capabilities.

Identify, evaluate, and implement external and internal technologies that can unlock smaller sample volumes, richer attribute profiles, higher throughput, improved sensitivity, or new classes of protein interaction and developability data.

Establish data standards, quality expectations, assay controls, and analytical frameworks that allow high-throughput measurements to be used confidently for model training, candidate triage, and program decision-making.

Ensure the function generates high-quality, decision-enabling data across Discovery, Candidate Selection, and early Development, including developability, stability, specificity, affinity, kinetics, and manufacturability-relevant attributes.

Drive operational excellence across the function, including prioritization, resource planning, milestone delivery, metrics, continuous improvement, and clear communication of tradeoffs.

Represent the function with executive stakeholders and external partners, translating complex scientific strategy into clear, compelling, and actionable plans.

Leadership Responsibilities

Lead as a strong people leader and culture builder who develops trust, accountability, scientific ambition, and collaboration across a multidisciplinary organization.

Build, coach, and develop a high-performing team of managers, senior scientists, and technical experts, creating clear growth paths and succession strength within the function.

Guide the team through transition with empathy and clarity while raising the technical bar for platform innovation, cross-training, and multidisciplinary biophysics.

Foster an inclusive, transparent, and feedback-rich environment where individuals are empowered to take initiative, share knowledge, and continuously improve.

Set a high bar for both technical excellence and partnership, making collaboration across functions a visible standard for success.

Partner effectively across functions to advance shared company goals.

The Ideal Candidate will have:

Ph.D. in Biophysics, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, Synthetic Biology, Protein Engineering, or a related scientific discipline; or equivalent depth of industry experience.

12+ years experience in biopharma, biotechnology, synthetic biology, protein engineering, or a related field, with substantial leadership experience in protein analytics, biophysics, developability, and protein-protein interaction characterization.

Significant progressive experience in biopharma, biotechnology, synthetic biology, protein engineering, or a related field, with substantial leadership experience in protein analytics, biophysics, developability, and protein-protein interaction characterization.

A track record of building, inventing, or scaling novel assay platforms for protein therapeutics, especially miniaturized, pooled, multiplexed, microfluidic, barcode-enabled, sequencing-enabled, cell-based, or nanoscale biophysical or biochemical measurements.

Demonstrated ability to move beyond single-sample, low-throughput paradigms and create experimental systems that generate high-dimensional, quantitative data at the scale needed for AI/ML-enabled protein design.

Deep technical expertise across conventional analytical and biophysical methods, such as HPLC/UPLC (SEC, RP, HIC, IEX), LC/MS, CE-SDS, cIEF, DSF, DSC, DLS, SEC-MALS, SPR, BLI, and related technologies.

Strong understanding of protein-protein interaction measurement, including affinity, kinetics, specificity, cross-reactivity, epitope/binning, avidity, and context-dependent binding behavior.

Strong quantitative mindset and experience using data quality, assay statistics, modeling, and informatics to shape scientific strategy, technology investment, and operational decision-making.

Experience partnering closely with prototyping, automation, engineering, computational, and technology teams to translate exploratory assay concepts into robust, reproducible, and scalable capabilities.

Demonstrated success as a senior people leader, including leading leaders, developing senior scientific talent, and scaling high-performing teams through periods of change.

Exceptional collaboration and communication skills, with a clear track record of influencing across complex, matrixed organizations and engaging executive stakeholders with clarity, candor, and credibility.

Who Will Love This Job:

This is an opportunity to define the future of biophysics at Generate:Biomedicines. You will lead an exceptional team at the intersection of biological engineering, machine learning, and medicine, and you will shape how next-generation analytical and protein interaction technologies unlock scale, insight, and speed for our protein design platform. Your leadership will directly influence both the science we build and the culture we create.

About Generate:Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

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Worksite address

somerville, MA, 02145, US

Who can apply

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