About this opportunity
GlaxoSmithKline lists this Senior Medical Director, Oncology Clinical Development - Sarcoma opportunity in waltham, Massachusetts. Review the employer’s description below for duties, qualifications and application requirements.
Job description
For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.
The Senior Medical Director, Oncology Clinical Development - Sarcoma, is a senior physician leader within the clinical programme team, providing medical oversight, strategic clinical insight, and a patient-centred perspective across the design, conduct, and interpretation of clinical studies. This role ensures that medical considerations, patient safety, and clinical integrity are consistently applied across studies within a programme.
Operating within the clinical strategy defined by the Clinical Development Lead (CDL), the Senior Medical Director partners closely with the Senior Scientist and cross-functional teams to guide the integration of physician expertise into study execution and programme-level decision-making. The role serves as a senior member of the Clinical Matrix Team (CMT), contributing to complex clinical decisions, regulatory interactions, and external scientific engagement.
The Senior Medical Director provides matrixed oversight to the clinical team within the programme, supporting consistency of clinical judgement, safety evaluation, and medical interpretation across studies.
PLEASE NOTE: This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK's Switzerland (Zug), UK (Stevenage or London HQ) or US(PA or MA) sites.
In This Role You Will:
Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation
Provide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standards
Interpret complex clinical and safety data, generating insights that inform programme-level decisions led by the CDL
Partner with the Senior Scientist and cross-functional teams to ensure medical considerations are integrated across study execution and programme delivery
Provide senior medical input into protocol development and study design, ensuring clinical relevance and patient-centred design within the clinical strategy defined by the CDL
Serve as a senior member of the CMT, influencing study-level and programme-level decision-making
Engage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums
Provide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capability
Detailed Responsibilities:
Medical Monitoring and Safety Oversight
consistency in approach, patient safety, and protocol adherence
Guide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit-risk evaluation across the programme
Participate in and contribute to safety review forums (e.g., SRT, IDMC), providing senior physician perspective on complex safety questions
Ensure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standards
Study Design and Execution
Provide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDL
Guide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or multi-study programmes
Support resolution of complex medical questions arising during study conduct, applying clinical judgement to inform programme-level decision-making
Ensure consistency of medical considerations across multiple studies within the programme
Data Interpretation and Scientific Contribution
Interpret complex clinical data across studies, integrating findings to inform programme-level insights on safety, efficacy, and patient impact
Contribute to programme-level data interpretation and support CDL-led benefit-risk assessment and clinical positioning
Guide development of scientific communications, including publications, congress materials, and clinical summaries
Maintain deep understanding of disease biology, evolving treatment paradigms, and competitive landscape to inform clinical interpretation and programme strategy
Regulatory and External Engagement
Contribute senior medical expertise to regulatory interactions and Health Authority discussions, including responses to complex clinical and safety queries
Represent the programme at advisory boards, steering committees, and external scientific forums, providing senior physician perspective on clinical data and programme direction
Engage with KEEs and scientific collaborators to support programme development, scientific exchange, and external credibility
Lead or contribute to the clinical and technical diligence assessment of business development opportunities
Cross-functional Collaboration and Clinical Matrix Team
Serve as a senior member of the Clinical Matrix Team (CMT), influencing cross-functional alignment and programme-level decision-making
Contribute medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussions
Collaborate across functions to ensure alignment on safety, data interpretation, and clinical positioning across the programme
Lead or contribute to Oncology Clinical Development-wide initiatives and workstreams
People Leadership & Capability Development
Provide oversight, guidance, and mentorship to clinical scientists within the programme, supporting consistency and quality of medical input across studies
Support development of clinical capability within the medical team, including coaching on medical monitoring, data interpretation, and external engagement
Contribute to talent development, performance discussions, and capability building within Oncology Clinical Development
Basic Qualifications:
Medical degree and completion of advanced specialty training,fellowshipor country-equivalent higher-level qualification in medical oncology, pediatric oncology or hematology.
Experience in sarcoma oncology, including leading drug development.
Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes
Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies
Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks
Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions
Preferred Qualifications:
Deep expertise in soft tissue sarcoma and osteosarcoma, including experience leading or supporting clinical development programs across early and/or late-stage clinical studies.
Strong scientific communication and stakeholder engagement skills, with the ability to influence internal and external audiences
Deep experience in oncology clinical development across multiple studies or programmes, including Phase I-III
Experience contributing to or leading aspects of regulatory interactions (e.g., IND, scientific advice, NDA/MAA)
Demonstrated experience engaging with KEEs, advisory boards, and scientific communities in oncology
Track record of scientific publications and congress presentations
Deep understanding of oncology disease biology and the evolving treatment landscape across solid tumours and/or haematological malignancies
Experience contributing to clinical and technical diligence for business development opportunities
Clinical Data Interpretation, Clinical Pharmacology, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction* If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,250 to $473,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or
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Worksite address
waltham, MA, 02254, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.