Senior Oligonucleotide Chemist — Synthesis & Analytics

Job description

At Regeneron Genetic Medicines, we are driven by a mission to transform the treatment of serious diseases through groundbreaking genetic therapies. Our team is at the forefront of innovation, applying cutting‑edge science to improve patient outcomes and redefine the future of medicine.

We are seeking a highly motivated and detail‑oriented Senior Associate Scientist to join the RGM R&D Chemistry team with a focus on oligomer and oligonucleotide synthesis, purification, and analytical characterization. The successful candidate will support the design and execution of solid‑phase synthesis workflows, contribute to the preparation of modified RNA‑related materials, and generate high‑quality analytical data to guide platform research and development. This role offers an opportunity to work at the interface of synthetic chemistry, analytical characterization, and RNA therapeutic innovation while contributing to programs that may meaningfully advance future medicines.

What You'll Do

Execute solid‑phase oligomer and oligonucleotide synthesis using automated synthesis platforms, including preparation of reagents, setup of synthesis cycles, incorporation of standard and chemically modified amidites, and on‑bead or post‑synthetic modifications as needed.

Support synthesis of RNA‑related constructs of varied lengths, formats, and chemical modification to enable discovery, platform development, and cross‑functional program needs.

Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency.

Perform purification of synthesized oligomers using appropriate chromatographic techniques, including size‑exclusion, anion‑exchange, reverse‑phase, and ion‑pair reverse‑phase methods.

Characterize purified materials using analytical methods such as LC‑MS, HPLC/UPLC, UV‑Vis, and other orthogonal techniques to confirm identity, purity, concentration, and product quality.

Analyze and interpret experimental results, summarize findings clearly, and recommend next steps to support iterative chemistry design and platform advancement.

Maintain accurate, complete, and timely experimental records in accordance with laboratory standards, safety expectations, and internal documentation practices.

Support routine operation, maintenance, troubleshooting, and inventory management for key synthesis and analytical instrumentation, reagents, and laboratory supplies.

Collaborate effectively with chemists, biologists, analytical scientists, and project teams to advance RGM Chemistry objectives and communicate technical progress in team discussions.

Let's Find Out If We're a Fit

B.S. in chemistry, biochemistry, chemical biology, biology, or a related scientific discipline is required; Masters degree is preferred

Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience required.

Hands‑on experience with solid‑phase organic synthesis is preferred, particularly oligonucleotide, peptide, oligomer, or related polymer/biopolymer synthesis workflows.

Nice to have - familiarity with automated synthesis platforms such as MerMade, OligoSynt, or comparable oligonucleotide/oligomer synthesizers is highly desirable. Experience with purification and analytical characterization methods, including SEC, AEX, RP‑HPLC or RPIP‑HPLC, and LC‑MS.

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit For other locations, additional information will be provided during the recruitment process.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$80,300.00 - $131,100.00

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Who can apply

Review the original listing for work authorization, qualifications and employer requirements.