About this opportunity
Regeneron Pharmaceuticals, Inc (USA) lists this Senior Principal Scientist, Bispecifics & Antibody Engineering opportunity in village of tarrytown, New York. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Build our future together: At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Principal Scientist to lead a small team within our Bispecific Antibodies group, using structural insight to design, engineer, and optimize next-generation bispecific and multispecific antibody therapeutics. In this role, you will integrate structural data with AI/ML-enabled design and high-throughput, automated experimental validation, co‑championing programs with biology leads from concept to IND. This position offers the opportunity to contribute to a fast‑growing, science‑driven organization making a meaningful difference to patients worldwide.
Discover your role:
Set molecular design strategy for bispecific and multispecific antibodies based on target biology, structure, and mechanism of action
Lead structure‑guided design of novel formats, including binding‑arm selection, epitope and geometry optimization, and chain pairing, using tools such as AlphaFold, Rosetta, MOE, and PyMOL
Drive protein engineering campaigns that integrate AI/ML and in silico design into iterative design‑build‑test‑learn cycles with computational partners
Oversee high‐throughput construct generation, expression, purification, biophysical characterization, and cell‑based functional assays to rank molecules on activity and developability
Build curated engineering datasets and design rules that strengthen the bispecific platform across oncology, immunology, and infectious disease
Lead, mentor, and develop a team of scientists, partnering with internal and external groups to advance the pipeline
Apply structural biology to solve hard antibody and protein engineering problems, combining experimental data with computational and AI/ML‑driven design
Lead multiple projects in parallel with strong organization and flexibility, communicating structural insights clearly to non‑specialist audiences
This role requires:
Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field
8+ years of post‑Ph.D. experience, including at least 5 years in the biotech/pharmaceutical industry
At least 2 years of direct people management experience with a record of success developing scientists
A record of innovation and research accomplishments in antibody or protein therapeutic engineering (publications, patents, or programs advanced into development)
Experience engineering bispecific or multispecific antibody formats, with deep hands‑on expertise in molecular cloning, protein expression, purification, and biochemical/biophysical characterization
Experience with mammalian cell culture and cell‑based assay development
Preferred: experience applying computational design and AI/ML tools to protein engineering, and with automated or high‑throughput protein engineering workflows
We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.
Location: Tarrytown, NY; Work model/flexibility: Onsite
Salary Range (annually) $150,500.00 - $245,500.00
Benefits
annual bonuses or other incentive plans
equity awards
pension or retirement benefits
401(k) company match
health and wellness programs
fitness centers
insurance benefits (e.g. medical, dental, vision, life and disability)
paid time off
family support benefits
Regeneron is a leading biotechnology company that invents life‑transforming medicines for people with serious diseases. Founded and led for over 30 years by physician‑scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA‑approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.
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Who can apply
Review the original listing for work authorization, qualifications and employer requirements.