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Job description
We are growing our DMPK team at Axonis Therapeutics with a new Senior/Principal Scientist, DMPK role reporting to the Senior Director, DMPK.This role will be highly visible, collaborating cross-functionally from discovery through clinical development. You will drive the DMPK strategy at the program level.This position will work closely with Medicinal Chemistry on small molecule optimization toward development candidates within the CNS area. You will continue into early clinical development working closely with Clinical Pharmacology.The successful candidate will bring experience working with project teams at the intersection of Chemistry, Biology, and Toxicology.Axonis is Boston based with a global footprint and hybrid work environment.
Responsibilities:
DMPK representative supporting project decisions from discovery through clinical stages
Design and interpret ADME, PK, and PK/PD studies from routine SAR to mechanistic insights working with external partners
Drive DMPK design strategy in close collaboration with Medicinal Chemistry
Perform human PK and dose projections, supporting the progression of lead compounds through the screening cascade
Author DMPK sections of regulatory documents and respond to queries
Work collaboratively with the Senior Director of DMPK to design the overall ADME/DMPK strategy for the company
Cross-Functional Collaboration:
Work with in vivo pharmacology to interpret exposure–efficacy data and guide compound progression
Contribute to safety and toxicology strategy by ensuring compounds meet advancement criteria
Collaborate cross functionally and within matrixed environment to advance projects to required milestones
External Collaboration
Interface with external ADME/DMPK CRO partners to support compound screening and optimization
Contribute to experimental planning, data review, and milestone tracking with vendors
Ensure high standards of data integrity, documentation, and reproducibility
Program Contribution & Scientific Communication
Present program data and recommendations at internal governance meetings
Provide scientific input into portfolio discussions from an ADME/PK perspective
Thorough, meticulous, and detail-focused approach to data handling and documentation
Contribute to a collaborative, high-rigor company culture.
Required Skills & Qualifications:
PhD in Pharmacokinetics, Pharmaceutics, or related field with a minimum of 3 years of industry experience
3+ years as a small molecule DMPK project representative/lead on cross functional project teams
Experience with human PK and dose projections
Interest in both discovery and development stage DMPK
Some experience with PK/PD modeling and simulation
Clear and effective communicator
Collaborative mindset, creativity, “can do attitude” and adaptability in a nimble, entrepreneurial biotech environment
Legally authorized to work in the US via US citizenship or residency
Preferred:
Experience authoring regulatory documents a plus but not required
Interest or experience in supporting PBPK outsourcing
Expertise in supervising regulated bioanalysis
About Axonis Therapeutics:
Axonis Therapeutics is a Boston-based, neuro-focused biotechnology company developing a portfolio of first- and best-in-class medicines targeting KCC2, a genetically validated critical mediator of inhibition within the brain. Axonis has brought together a collaborative, creative and determined team of world-leading experts in neuroscience and drug development to discover and develop novel treatments for epilepsy, pain and other neurological disorders. With its proprietary KCC2 discovery engine based on breakthrough science from Boston Children’s Hospital, Harvard and Laval University, Axonis is poised to make a real difference for patients, their families, and the global healthcare system.
EEOC Statement: Axonis believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. In addition, Axonis will provide reasonable accommodations for qualified individuals with disabilities.
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Worksite address
boston, MA, 02298, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.