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Job description
Senior Research Associate, High-Throughput RNA Production
Cambridge, MA
About Sail
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ oreRNA), and an industry-leading platform of programmable nanoparticles,utilizingnatural components, to unlock comprehensive programming of medicines for the first time. Byleveragingcutting-edgeeRNAand nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques toidentifyand design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.
The Role
The Senior Research Associate, high-throughput (HTP) RNA production, serves an important role in generating RNAs to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role will carry out end-to-end process of high-throughput RNA production, from template plasmid cloning to RNA generation and clean up. The successful candidate is organized, attentive to details, a fast learner with a strong sense of responsibility who takes pride in his/her work. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients’ lives.
Responsibilities
Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
Determine circularization efficiency and impurity levels by running analytic assays
Coordinate DNA synthesis and scale-up orders with external vendors
Manage raw material and RNA inventories
Collaborate with automation engineer to improve process workflow
Maintain detailed documentation in electronic lab notebooks
Present findings clearly to platform teams and contribute to scientific discussions and decision-making
Qualifications
B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
Ability to manage multiple tasks at once efficiently
Strong collaborative spirit and communication skills
Preferred Qualifications
Experience in molecular biology including cloning, RNA production and purification
Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
Experience with automated liquid handling systems (e.g., Hamilton) and high-throughput laboratory workflows
Experience using data analysis and information management tools, such as Excel, Graphic Prism, SnapGene, Benchling
Experience in inventory management
Salary Range: $75,000 - $95,000
Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.
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Worksite address
cambridge, MA, 02140, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.