About this opportunity
Healthcare Recruiters International lists this Senior Scientist opportunity in cedar park, Texas. Review the employer’s description below for duties, qualifications and application requirements.
Job description
The role
You’ll own end-to-end development and manufacturing of real-time PCR reagents—from primer/probe design through scale-up, QC, and lot release. If you’re equal parts designer, optimizer, and disciplined documenter, you’ll thrive here.
What you’ll do
Design highly specific primers/probes (hydrolysis/other chemistries) with rigorous in-silico analysis (BLAST, cross-reactivity, dimer/secondary structure, multiplex compatibility).
Develop & optimize qPCR assays (singleplex - multiplex): annealing temps, Mg/dNTP balance, enzyme selection, inhibitors tolerance, efficiency (90-110%), linearity, and reproducibility.
Formulate master mixes and buffers; evaluate stabilizers and excipients; contribute to lyophilized/liquid formats and fill/finish.
Validate assays to CLSI-style expectations (e.g., LoD, precision, inclusivity/exclusivity, interference, carryover); plan and execute real-time/accelerated stability studies.
Transfer to manufacturing: create DMR/lot records, SOPs, WI/batch records; train production; support CAPA/NCs.
QC & lot release: define acceptance criteria (Cq, efficiency, R2, NTC behavior), build control strategies, and troubleshoot failures fast.
Platform breadth: qualify methods across common thermocyclers and extraction workflows; ensure cross-platform thermal protocols when feasible.
Data & documentation: keep airtight ELN, author clear reports, and communicate results crisply to Ops/QA/Reg.
Minimum qualifications
MS/PhD in Molecular Biology, Biochemistry, Bioengineering, or related field.
3+ years hands-on qPCR assay design and wet-lab optimization (industry preferred).
Fluency with Primer3/PrimerQuest, OligoAnalyzer, NCBI BLAST, and multiplex design principles.
Proven track record taking assays from concept - validated method - manufactured product.
Strong grasp of GxP/ISO-style documentation and change control.
Comfort analyzing data in Excel/R/Python or platform software (e.g., QuantStudio/CFX Manager)
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Worksite address
cedar park, TX, 78613, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.