About this opportunity
BigHat Biosciences lists this Senior Scientist, Developability [Contract] opportunity in san mateo, California. Review the employer’s description below for duties, qualifications and application requirements.
Job description
Description
Department: Lab Science
Location: San Mateo, CA
Description
The role:
BigHat Biosciences is looking for a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late stage drug candidates from our Milliner Platform for AI-designed therapeutics. This is a lab-based 12-month contract role, with the possibility but no guarantee of conversion to full-time position. You'll spend the majority of your time at the bench executing complex stability studies.
Key Responsibilities
Lead, design, and execute in-use dose solution studies to assess drug compatibility with administration materials.
Develop highly sensitive protein characterization methods (qSEC, RP-HPLC, CEX, particle counting, etc) for assessing drug quality and recovery.
Support late-stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates.
Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
Communicate with and manage external CROs for testing and analytics.
Interpret and communicate scientific findings, propose next steps, and broadcast clearly across the organization.
Proactively identify and scope state-of-the‑art analytical tools and developability technologies.
Skills Knowledge And Expertise
PhD in Biochemistry or relevant discipline with 5+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
Experience developing and optimizing sensitive analytical chromatography-based methods is a must.
Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS.
Track record of translating complex data into clear results and recommended actions.
Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.
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Worksite address
san mateo, CA, 94409, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.