About this opportunity
Flagship Pioneering lists this (Senior) Scientist, Machine Learning opportunity in cambridge, Massachusetts. Review the employer’s description below for duties, qualifications and application requirements.
Job description
What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?
COMPANY DESCRIPTION
Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
THE ROLE
Expedition is seeking a motivated and innovative (Senior) Scientist, Machine Learning to join our team. In this role, you will play a critical role in developing, evaluating, and applying machine learning approaches that connect Expedition’s proprietary chemoproteomics data with quantum chemistry, electronic structure, and generative molecular design. The successful candidate will combine strong expertise in modern machine learning with a deep understanding of molecular representation, quantum chemistry, and computational drug discovery to drive impact across Expedition’s drug discovery programs.
This individual will contribute to the advancement of a state-of-the-art AI platform for covalent drug discovery, with a focus on linking large-scale atom-precision experimental data to physically meaningful features such as electronic structure, reactivity, and DFT-derived descriptors. A key part of the role will be applying generative models directly to active drug discovery programs in close partnership with medicinal chemistry, while developing rigorous benchmarks to evaluate model performance and guide platform improvement. The ideal candidate is highly collaborative, scientifically rigorous, comfortable with hands-on data curation, and capable of independently driving projects in a fast-paced research environment.
KEY RESPONSIBILITIES
Develop, implement, and evaluate innovative machine learning methods for connecting (macro-)molecular quantum chemical features, reactivity modeling,
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Worksite address
cambridge, MA, 02140, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.