Senior Scientist, siRNA therapeutics

Job description

Qilu Pharmaceuticals is a leading pharmaceutical and biopharmaceutical company in China, with 3 innovation centers in the US. We are seeking highly motivated and experienced scientists with strong assay development expertise to join our collaborative and fast-growing RNA Therapy team.

The successful candidate will play a key role in advancing innovative siRNA therapeutics for the treatment of serious diseases, including metabolic and liver diseases, neurological disorders, and ocular disease.

Primary Responsibilitie

sLead and execute preclinical screening and evaluation of siRNA candidates to support lead identification and candidate selection through integrated in vitro and in vivo studie

sInvestigate target biology and mechanism of action; design and conduct proof-of-concept studies to validate therapeutic targets in collaboration with internal teams and external partner

sDevelop, optimize, and implement cellular and biochemical assays to support drug discovery and preclinical research activitie

sCollaborate closely with cross-functional teams, including chemistry, non-clinical development, bioinformatics, and external CRO partner

sManage multiple projects and priorities simultaneously while delivering high-quality results within established timeline

sDemonstrate scientific creativity, critical thinking, and a strong commitment to innovatio

nMaintain compliance with applicable SOPs and laboratory standards; provide technical guidance and training to junior team members as neede

dPresent scientific findings to project teams, leadership committees, and external collaborators. Communicate effectively across functions and organizational level

s

Qualifications and Experien

cePh.D. in Molecular Biology, Pharmacology, Neuroscience, or a related discipline, with: 3+ years of industry experience in biotechnology or pharmaceutical research; or 5+ years of relevant postdoctoral experienc

e.Experience working with siRNA, ASO, or other oligonucleotide therapeutics is highly preferr

edExtensive hands-on experience with RT-qPCR, ELISA, Western blotting, mammalian cell culture, animal handling, tissue collection, and tissue processing is requir

edPreferred technical skills include primary neuronal cell culture, stem-loop qPCR, and experience with rodent dosing techniques, including tail vein injection and intracranial administrati

onAdditional Qualificatio

nsDemonstrated record of scientific achievement through high-quality publications, patents, or drug discovery contributio

nsStrong experimental design, data analysis, and problem-solving skil

lsExcellent organizational and project management abilities, with a proven ability to work independently and manage multiple prioriti

esThrives in a fast-paced, collaborative, and multidisciplinary research environmen

t.Excellent verbal, written, and presentation skil

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Worksite address

boston, MA, 02298, US

Who can apply

Review the original listing for work authorization, qualifications and employer requirements.