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Job description
Senior Scientist in Sterile Oligonucleotide Drug Product Development
focused on developing and optimizing formulations and manufacturing processes for oligonucleotide therapeutics, primarily in CNS and eye indications.
Responsibilities
conduct hands-on formulation work
develop scalable processes from R&D to manufacturing
perform physicochemical and biophysical characterization
author technical and regulatory documents
support equipment selection
oversee process validation
assist manufacturing operations
Requirements
PhD in Bio/Chemical Engineering, Pharmaceutical Sciences, or related field with 4+ years industry experience; or MSc with 6+ years; or BSc with 10+ years.
Must have at least one year of experience in oligonucleotide or mRNA sterile drug product development.
Preferred skills
expertise in oligonucleotide conjugates, delivery routes (intrathecal, ocular, IV), analytical characterization (HPLC, LC-MS, DSC, etc.), bioconjugation chemistry, and high-throughput screening.
HighValue
expertise in oligonucleotide formulations, conjugates, and processes
experience with ASO-peptide/antibody conjugates
familiarity with regulatory standards (FDA, EMA, ICH)
Location
Bedford, MA, transitioning to Waltham, MA; on-site role with ~10% travel.
Salary & Benefits
competitive salary ($160K-$173K), benefits, and an innovative biopharma environment dedicated to RNA medicines targeting CNS and ocular diseases.
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Worksite address
bedford, MA, 01730, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.