About this opportunity
PacBio lists this Senior Staff Engineer, Software opportunity in menlo park, California. Review the employer’s description below for duties, qualifications and application requirements.
Job description
PacBio (NASDAQ PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.
Position Summary
The Senior Staff Software Engineer is responsible for designing, developing, and delivering business-critical instrument control software for next-generation sequencing platforms. This is a highly visible, cross-functional role that works closely with mechanical, electrical, firmware, and systems engineering teams at PacBio. This role is ideal for a deeply technical engineer who thrives on solving complex system-level challenges and driving high-impact software solutions at the intersection of hardware and software.
Responsibilities
Own and deliver business-critical instrument control software spanning multiple subsystems, directly impacting instrument performance, reliability, and customer experience
Drive technical design and implementation for complex, high-risk areas, independently defining approach and managing technical risk
Collaborate cross-functionally with mechanical, electrical, firmware, and systems teams to ensure robust hardware-software integration and clear requirements
Identify and resolve systemic issues in performance, reliability, and scalability, including proactively addressing technical debt
Lead design and code reviews while contributing hands-on development in C#/.NET, ensuring high-quality, maintainable software
Influence system architecture and technical direction, and mentor engineers to elevate team-wide engineering standards
Required Qualifications
Bachelor’s degree in Computer Science, Engineering, or a related discipline
10+ years of software engineering experience
Deep expertise in C#/.NET and proficiency in Python
Strong experience with real-time or embedded systems and hardware-software integration
Experience working with hardware systems such as robotics, optical systems, environmental sensors, or motion control
Strong proficiency with Linux environments
Solid understanding of software architecture, design principles, and best practices
Experience developing instrument control software, user interfaces, and system-level integrations
Experience designing and implementing APIs (e.g., RESTful services)
Demonstrated ability to independently drive complex technical projects from concept to production
Excellent interpersonal, written, and verbal communication skills
Preferred Experience
Experience developing scientific instrumentation
Master’s degree or higher in a technical field
Experience working with firmware and low-level system interactions (e.g., FPGA interfaces)
Experience with Agile software development methodologies
Experience with DevOps practices, CI/CD pipelines, and automated testing frameworks
Experience in life sciences, biotech, medical devices, or other regulated environments
Candidates must have current authorization to work in the United States without the need for present or future sponsorship.
You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.
All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
Salary Range
$195,900.00 - $293,900.00
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at , or for assistance.
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Worksite address
menlo park, CA, 94029, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.