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Job description
Key Responsibilities
Contribute to the scientific execution of ASO/siRNA discovery programs targeting monogenic cardiomyopathies, from target evaluation through candidate and lead selection.
Develop, optimize, and apply molecular, cellular, and biochemical assays (including qPCR/dPCR, reporter assays, ELISA, MSD-ECL, and automated capillary western blotting) to quantify RNA and protein modulation.
Collaborate closely with chemistry, bioinformatics, and translational research teams to advance oligonucleotide therapeutics from discovery through candidate selection.
Maintain accurate experimental documentation and reports
Present results at cross-functional team meetings
Required Qualifications
B.A. and 5 years of biotech/pharma lab experience; or M.A. and 3 years of biotech/pharma lab experience
Expertise in RNA targeting oligonucleotide therapeutics, including evaluations of ASO/siRNA screening, mammalian cell culture, various cell transfection methods, and various quantitative assays for nucleic acids and proteins.
Ability to work independently with flexibility to adapt with company priorities
Time management and organizational skills to enable high quality effort towards multiple projects or experiments concurrently
Strong organization and record keeping habits in electronic notebooks
Preferred Qualifications
Experience with targeted oligonucleotide delivery platforms.
Expertise in iPSC-derived cardiomyocyte biology, cardiac disease modeling, and functional cardiac assays.
Experience with RNA-targeted therapeutics approaches, including oligonucleotide-based modalities.
Broad expertise in modern molecular biology techniques, including CRISPR genome engineering, viral vector systems (AAV/lentivirus), flow cytometry, next-generation sequencing, and high-content imaging.
Experience establishing discovery platforms that integrate computational predictions with experimental validation for target discovery and prioritization.
Strong publication and/or patent record in RNA therapeutics or related fields.
Demonstrated track record of mentoring scientists, building technical capabilities, and advancing discovery programs from concept through candidate selection.
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Worksite address
cambridge, MA, 02140, US
Who can apply
Review the original listing for work authorization, qualifications and employer requirements.